The Mercedes-Benz W221 model use the new EZS with the NEC processor marked JURA (also named EIS-electronic ignition switch). And Mercedes CAN filter will work with the EZS module. For installation remove EZS from car.
MB CAN filter to select:
MB CAN Filter 5 in 1 for W221 W204 W212 W166 and X166
MB CAN Filter 8 in 1 for W221 W204 W212 W166 and X166 W172 W218 W246
MB CAN Filter 12 in 1 for W221 W204 W207 W212 W166 X166 W218 W172 W246 W176 W117 W156
Step-by-step installation instruction:
1- prepare Mercedes CAN filter board:
check – resistor 121 must be soldered and solder second configuration points like in pictures.
2- Remove from EZS board SMD part marked with red “X”.
With short, good isolated wire connect Mercedes CAN filter to EZS board according picture: 1-1 (C1H), 2-2(C1L), 3-3(C2H), 4-4(C2L), 5- 5(GND), and 6-6 (+5V).
Mercedes S-class W221 another type: